Been through that once in a part of the world where the aircraft were all on an airway corridor. After that, I would take a look at the current wind arrow. If it is straight forward or behind, then consider flying offset.
"C-GOIR, an Airbus A321neo operated by Air Transat was conducting a flight from Manchester International Airport (EGCC), UK, to Toronto/Lester B. Pearson International Airport (CYYZ) ON. During cruise, the aircraft experienced wake turbulence from an opposite direction Airbus A380, 1000 feet above. Two cabin crew members sustained minor injuries and one of these members was considered incapacitated and unable to perform their duties. First aid was provided, and the flight continued to the destination without further incident."
....from TSB.
A380 Turbulence In Cruise
Moderators: lilfssister, North Shore, sky's the limit, sepia, Sulako
Re: A380 Turbulence In Cruise
Accident: Transat A21N and Ethiopian A35K near Gander on Jul 27th 2025, wake turbulence from A35K causes injuries on A21N
By Simon Hradecky, created Wednesday, Aug 6th 2025 16:37Z, last updated Wednesday, Aug 6th 2025 16:37Z
An Air Transat Airbus A321-200N, registration C-GOIR performing flight TS-207 from Manchester,EN (UK) to Toronto,ON (Canada) with 196 people on board, was enroute at FL340 about 170nm north of Gander.
An Ethiopian Airbus A350-1000, registration ET-BAX performing flight ET-501 from Washington Dulles,DC (USA) to Addis Ababa (Ethiopia), was enroute at FL350 about 170nm north of Gander overflying the Airbus A21N.
The Canadian TSB reported the A21N experienced wake turbulence from the aircraft (thought to have been an A388) 1000 feet above, two cabin crew received injuries incapacitating one of them. First aid was provided and the flight continued to destination.
By Simon Hradecky, created Wednesday, Aug 6th 2025 16:37Z, last updated Wednesday, Aug 6th 2025 16:37Z
An Air Transat Airbus A321-200N, registration C-GOIR performing flight TS-207 from Manchester,EN (UK) to Toronto,ON (Canada) with 196 people on board, was enroute at FL340 about 170nm north of Gander.
An Ethiopian Airbus A350-1000, registration ET-BAX performing flight ET-501 from Washington Dulles,DC (USA) to Addis Ababa (Ethiopia), was enroute at FL350 about 170nm north of Gander overflying the Airbus A21N.
The Canadian TSB reported the A21N experienced wake turbulence from the aircraft (thought to have been an A388) 1000 feet above, two cabin crew received injuries incapacitating one of them. First aid was provided and the flight continued to destination.