Bear in mind I only usually cruise at 7-8000
Unfortunately therein lies the problem if you are departing from YTZ and wanting to go north in a single engine prop.
On either east/west configuration at YYZ the arrivals can descend to 8000ft in their airspace (lower once in the early descent areas and arrival box) and departure can climb to 7000ft under the arrival airspace.
There is no "direct" route on either configuration northbound that wouldn't put you in conflict with either departure or arrival traffic. On the 24s you would be going over the arrival box with the straight in fixes being cleared to 8000 and 7000ft...and you also have the traffic that is being sequenced into the downwind from the North, West and South descending from 8000ft.
On the 06s...departure jets are climbing to 5000ft (unless jet turned) before talking to departure...you would have to be above 5000ft before expecting a turn northbound off the island. It would actually be easier on the 06s than on the 24s though as you don't have to be climbed over the lake.
It is not totally beyond the realms of possibility for 7000-8000ft off the island Northbound IFR to work. I would just say that 9 times out of 10 you would most likely get kept low and routed via KZ before being climbed as this keeps you clear of Pearson traffic.
Regarding your comment about departing ZBA. If you are going West then there should be no problem. If you are going north or north east bound you won't be climbed till north of the YYZ arrival or departure traffic and you will be pointed north to keep clear of Pearson. East or South East....it will be over the lake everytime....climbing along the shoreline puts you in conflict with the traffic mentioned above.
Hope this helps some.